Safe pressure monitoring for vaccine production

It may take up to 3 years to show bacteria, viruses or cell cultures into a vaccine. Since vaccines are injected straight into your body, safety and purity have the best priority in production. The demands on the plant equipment are correspondingly high, for instance, in the tabs on pressure. The PG43SA group of diaphragm pressure gauges from WIKA are tailored to the.
Designed completely in hygienic design: the diaphragm pressure gauges of the PG43SA series
Three instrument models to pick from
The hygienic instruments with flush, welded diaphragm elements are suitable for pressure monitoring in every areas of vaccine production. Mind-blowing applies, not only to the ?upstream? and ?downstream? stations, but additionally to the support processes.
You can find three 3A and EHEDG-certified models available:
PG43SA-S
PG43SA-D with integrated diaphragm element monitoring
PG43SA-C particularly compact with back mount process connection
Which variant a user chooses, and at which point along the way, depends on their safety requirements and the installation conditions ? although the model PG43SA-S already meets a large area of the requirements for pressure monitoring.
Critical situation instantly
The further the vaccine production progresses, the more valuable the merchandise becomes. During the ?downstream? filtration processes, the future active ingredient is increasingly purified. Here, pressure monitoring provides the decisive information as to whether the filters remain working correctly or are clogging up and ought to be replaced. The model PG43SA-S with red limit value marking, for example, enables a crucial situation to be detected, unmistakably, at a glance.
In filtration plant, pressure monitoring is used, among other things, to check on the filter status also to draw attention to any clogging of the filter in good time.
Problem-free installation
That the compact nature of the instruments can be important in this is illustrated by a filtration system at a vaccine manufacturer in China: in cases like this, a peristaltic pump conveys the active ingredient to the capsule filter via a hose. The challenge of the very cramped available space meant a little measuring instrument was required, and the model PG43SA-C met this.
The instrument could be easily mounted on the hose before and following the filter due to its process connection being integrated into the case ? a patented design. This measuring solution shows the operator if the pump and filter are working normally. The PC43SA-C supplies a good plan view because of this. Hence, it is also suitable for pressure monitoring in vertical pipelines.
The models in the PG43SA series, like all diaphragm pressure gauges, as a result of their mechanical principle, always reliably indicate the procedure pressure. They measure with high overload safety and independently of electricity. This meets the safety requirements, especially when transporting the intermediate products and the finished vaccine. These are transported in mobile tanks from the bioreactor via chromatograph and filtration systems to filling into ampoules.
Vaccine transport in mobile tanks is considered a particularly sensitive process step. The hygienic diaphragm pressure gauges of the PG43SA series provide all of the necessary pressure information anytime, independent of electrical power.
Multiple tasks in one application
When monitoring the pressure at the tanks, the PG43SA instruments fulfil several tasks: During transport, it is important to check whether the pressure remains constant. That is also a leak test: a falling pressure could be because of leaking valve or a damaged seal. After emptying the tank at the transfer point, one look at the display can determine whether there’s still pressure in the tank or whether it can be opened without danger. The same pertains to pressure monitoring during tank cleaning and the pressure test before refilling.
In tank applications, in addition to the measurement quality described, another advantage of diaphragm pressure gauges comes to the fore: the instruments utilize a ?dry? measuring cell. This eliminates the chance of product contamination by way of a system fill fluid, as is the case with conventional diaphragm seal systems. In this manner, they prevent potential damage which could amount to millions.
Further risk minimisation
In these and similar sensitive processes, the model PG43SA-D really helps to further minimise risks to the vaccine. The instrument has an integrated diaphragm element monitor with red/white indicator. In the unlikely event that the robust measuring element should break due to extreme process conditions or rough mechanical influences, the patented monitoring function immediately reports the damage with a ?red? indicator. A second barrier in the instrument maintains the separation of process and environment.
Ideal for CIP/SIP and autoclavable
Process reliability in vaccine production includes residue-free cleaning of the equipment after each batch. Because of their hygienic design, the PG43SA diaphragm pressure gauges are suitable for CIP/SIP cleaning processes and so are all autoclavable.
Note
You can find an overview and technical details of the PG43SA series hygienic diaphragm pressure gauges on the WIKA website or inside our flyer: ?Safe and reliable: Pressure displays in hygienic design?. You want to buy hygienic diaphragm pressure gauges? Inside our WIKA online-shop you will find a few of our standard designs. When you have any questions, your contact will gladly assist you to.
Also read our articles
Pressure gauges for pharmaceutical processes: Flush-mounted dry measurement
Hygienic pressure gauge: IP68 with cleaning from the exterior
The next video also informs you concerning the PG43SA instruments:

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